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MicroRNA-126 inhibits the proliferation of lung cancer cell line A549
Asian Pacific Journal of Tropical Biomedicine ; (12): 239-242, 2015.
Artigo em Chinês | WPRIM | ID: wpr-500529
ABSTRACT

Objective:

To study the role of microRNA-126 in the development of lung cancer.

Methods:

The biological function of microRNA-126 was detected using EdU assay and CCK-8 assay;the target gene of microRNA-126 was analyzed using real time RT-PCR and Western blot assay.

Results:

In A549 cell line, overexpression of microRNA-126 inhibits the proliferation rate; VEGF is the target gene of microRNA-126; microRNA-126 exerts its function via regulating VEGF protein level.

Conclusions:

microRNA-126 inhibits the proliferation in A549 cell line.

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Asian Pacific Journal of Tropical Biomedicine Ano de publicação: 2015 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Asian Pacific Journal of Tropical Biomedicine Ano de publicação: 2015 Tipo de documento: Artigo