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Changes of TIZ expression in epithelial ovarian cancer cells
Asian Pacific Journal of Tropical Biomedicine ; (12): 157-161, 2015.
Artigo em Chinês | WPRIM | ID: wpr-500539
ABSTRACT

Objective:

To study the change ofTIZ expression in epithelial ovarian cancer cells.

Methods:

HO8910 cells were transinfected with siRNA to inhibit the expression ofTIZ. pcDNA3.1-TIZ vectors were combined to increase theTIZ expression level.The cell viability, colony forming efficiency and cycle distribution ofHO8910,HO8910/NC,HO8910/pcDNA3.1-NC,HO8910/TIZ-573 andHO8910/pcDNA3.1-TIZ were compared, and the invasion rate, migration rate and adhesion rate between5 groups of cells were compared.

Results:

Compared with those ofHO8910,HO8910/NC andHO8910/pcDNA3.1-NC, the cell viability, colony forming efficiency and cell cycle distribution ofHO8910/TIZ-573 were increased, while the indexes ofHO8910/pcDNA3.1-NC were decreased with statistical significant difference(P0.05).

Conclusions:

The expression ofTIZ can inhibit the proliferation of epithelial ovarian cancer cells.

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Asian Pacific Journal of Tropical Biomedicine Ano de publicação: 2015 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Asian Pacific Journal of Tropical Biomedicine Ano de publicação: 2015 Tipo de documento: Artigo