Clinical Observation of Metformin in the Treatment of Type 2 Diabetes with Non-alcoholic Fatty Liver Disease / 中国药房
China Pharmacy
;
(12): 4659-4661, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-500865
ABSTRACT
OBJECTIVE:
To observe the efficacy and safety of metformin in the treatment of type 2 diabetes(T2DM) with non-alcoholic fatty liver disease(NAFLD).METHODS:
106 patients with T2DM with NAFLD were randomly divided into control group and observation group. Control group was received health education about T2DM with NAFLD and living intervention(diabe-tes diet and physical therapy);observation group was additionally given Metformin tablet 0.5 g,orally,3 times a day. The treat-ment course for both groups was 12 weeks. Clinical efficacy,and liver fat content,BMI,FPG,IR,TG,TC,LDL-C,HDL-C,HbA1c before and after treatment,and incidence of adverse reactions in 2 groups were observed.RESULTS:
After treatment,liver fat con-tent and related index in 2 groups were significantly better than before(except HOMA-IR in control group),and observaton group was better than control group,the differences were statistically significant(P<0.05). The total effective rate in observation group was significantly higher than control group,the difference was statistically significant(P<0.05).CONCLUSIONS:
Based on the conventional treatment,metformin has good efficacy and safety in the treatment of T2DM with NAFLD.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
China Pharmacy
Ano de publicação:
2015
Tipo de documento:
Artigo
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