Protective Effects of Ketorolac Tromethamine Ophthalmic Gel against Staphylococcus aureus Corneal Ulcer in Rabbits / 中国药房
China Pharmacy
;
(12): 4388-4390, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-501109
ABSTRACT
OBJECTIVE:
To study protective effects of Ketorolac tromethamine ophthalmic gel against Staphylococcus aureus corneal ulcer in rabbits.METHODS:
S. aureus corneal ulcer in rabbits model was induced by corneal substance layer inoculation, and then divided into model group,positive control group (Clarithromycin ophthalmic gel),gel high-dose,medium-dose and low-dose groups(Ketorolac tromethamine ophthalmic gel 120,80,40 mg/ml),with 20 rabbits in each group. They were given re-levant medicine,once a day for 2 weeks. The keratopathy of rabbits was observed;the clinical efficacy and keratopathy score were compared. The change of ratina was observed under micrescope.RESULTS:
Compared with model group,the keratopathy score de-creased while total effective rate increased in positive control group and gel groups after medication, and the effects of gel high-dose and low-dose groups were significantly lower than that of positive control group,with statistical significance(P<0.05). The retina of rabbits had not affected by the experiment.CONCLUSIONS:
Ketorolac tromethamine ophthalmic gel has protective effect against S. aureus corneal ulcer in rabbits.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo prognóstico
Idioma:
Chinês
Revista:
China Pharmacy
Ano de publicação:
2015
Tipo de documento:
Artigo
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