Study on the Optimization of Matrix Formula of Lanlian Ertong Qingre Cataplasm / 中国药房
China Pharmacy
;
(12): 4412-4415, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-501124
ABSTRACT
OBJECTIVE:
To optimize the matrix formula of Lanlian ertong qingre cataplasm.METHODS:
Taking adhesion force,peel strength and sensory description as index,the ratio of matrix framework material(sodium polyacrylate-gan hydroxyl alu-minum-tartaric acid-glycerin) was optimized with orthogonal test. The single factor test was adopted to select adhesive and filler;the amount of penetrating agent azone was screened using the in vitro penetration amount of phillyrin.RESULTS:
The best matrix ratio of Lanlian ertong qingre cataplasm was sodium polyacrylate-gan hydroxyl aluminum-tartaric acid-glycerin(4.00.80.415);PVP K-90 was used as adhesive,and bolus alba as filler;penetration enhancers azone accounted for 2.0%. Validation test showed, prepared cataplasm had good appearance,could stick on the 5th or the 6th ball;it's peel strength was 7.5 N;all RSDs of score were lower than 4%(n=3).CONCLUSIONS:
The optimized matrix formula of Lanlian ertong qingre cataplasm is simple,stable and good in molding.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
China Pharmacy
Ano de publicação:
2015
Tipo de documento:
Artigo
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