Chiral Separation of Naproxen Enantiomers by Supercritical Fluid Chromatography / 中国药房
China Pharmacy
;
(12): 4789-4791, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-501205
ABSTRACT
OBJECTIVE:
To develop a method for the separation of naproxen enantiomers.METHODS:
The supercritical fluid chromatography(SFC)method was adopted. The chiral column,type and proportion of polar additive in mobile phase,back pres-sure and column temperature were optimized using the separation time,capacity factor,separation factor and separation degree as index.RESULTS:
The best condition was on the chiral column CHIRALPAK?AD-H,with polar additive of isopropanol (20%), back pressure of 170 bar,column temperature of 20℃and the detection wavelength of 283 nm. Under this condition,baseline sep-aration of naproxen enantiomers can be achieved;separation degree was 4.31 and separation factor was 1.90;RSD of precision,sta-bility and reproducibility tests were no more than 2.65%(n=5).CONCLUSIONS:
Established method is simple,reproducible and well-separated,and can be used for chiral separation of naproxen enantiomers.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
China Pharmacy
Ano de publicação:
2015
Tipo de documento:
Artigo
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