Effects of Different Doses of Sufentanil on Hemodynamics and Postoperative Stress Response of Children with Cardiac Surgery Anesthesia / 中国药房

ABSTRACT

OBJECTIVE:To explore the effects of different doses of sufentanil on hemodynamics and postoperative stress re-sponse of children with congenital heart disease in cardiac surgery anesthesia. METHODS:40 children underwent ventricular septal defect repair in our hospital were divided into group A,B,C and D with 10 cases in each group according to the dose of sufent-anil. Groups A,B,C and D were given intravenous injection of sufentanil(0.6,0.8,1.0,1.2 μg/kg)respectively during anesthe-sia induction. Heart rate(HR)and systolic blood pressure(SBP)of 4 groups were recorded before induction(T1),after induction (T2),intubation(T3),2 min after intubation(T4),5 min after intubation(T5),and 10 min(T6)after intubation. The contents of acetylcholine(ACH),cortisol,glucagon,IL-6 and lactic acid were recorded when getting into the operating room(t1),after intu-bation(t2),after spliting the sternum(t3),before rewarming(t4),10 minutes after the shutdown the CPB(t5)and 24 h after oper-ation(t6). RESULTS:There was no significant differences in HR and SBP between 4 groups at T1(P>0.05);but there was statis-tically significant difference between 4 groups at T2-T6(P0.05);but there was statistically significant difference between 4 groups at T2-T6 (P0.05);but there was statisti-cally significant difference between 4 groups at T5-T6(P<0.05). CONCLUSIONS:During pediatric cardiac surgery anesthesia,the concentration of sufentanil kept in 1.0μg/kg is the most suitable,and has small effect on hemodynamics and postoperative stress re-sponse.