Randomized study of Hemp seed pill plus lactulose oral solution regimen combination in the treatment of constipation induced by morphine-type drugs / 中国生化药物杂志

ABSTRACT

Objective To observe the efficacy in combination with Hemp seed pill and lactulose oral solution for treating cancer pafients with constipation induced by morphine-type drugs.Methods 62 Cancer patients with constipation induced by morphine-type drugs diagnosed by pathology or cytology were collected from January 2013 to July 2016 in Suzhou BenQ hospital for this study.The patients in study group received both Hemp seed pill and lactulose oral solution, and patients in control group received lactulose oral solution only.After treatment for 3 weeks,some indexes were observed, including outcomes in the overall response rates, Karnofsky score, weight.Results The total effective rate of the study group was higher than the control group(77.4%vs 48.3%, P<0.05), the difference was statistically significant;After treatment,Karnofsky score and the percentage of patients gaining weight in study group were markedly higher than those in control group,the difference was statistically significant(P<0.05).Conclusion Hemp seed pill combined with lactulose oral solution has a good clinical efficacy in treating pafients with constipation induced by morphine-type drugs, and can improve patient's quality of life.