Advances in genetics of intracranial aneurysm / 国际脑血管病杂志

ABSTRACT

Intracranial aneurysm is an abnormal bulging of intracranial artery wall. Its rupture can lead to subarachnoid hemorrhage. About 50% of patients with aneurysmal subarachnoid hemorrhage will die or have poor outcomes. At present, intracranial aneurysm is considered as a complex disease associated with genetic and environmental factors. Although the etiology of intracranial aneurysm is not completely clear, a lot of evidence has shown that the genetic factor plays an important role in the processes of its occurrence, development and rupture. This article reviews the advances in gene linkage research, genome wide association studies, and gene expression research in intracranial aneurysm in recent years.