Clinical outcome analysis of newborn in pregnant women with drug abuse / 中国小儿急救医学

ABSTRACT

Objective To observe the pregnancy outcome of perinatal in drugs abuse pregnant women.Methods The clinical data of 105 cases of newborn in pregnant women with drug abuse were analyzed retrospectively,including premature,neonatal asphyxia,low birth weight,neonatal respiratory distress syndrome (NRDS),intracranial hemorrhage,neonatal congenital malformation and death.Fifty cases of newborn of healthy pregnant women were selected as control group.The occurrence of neonatal withdrawal syndrome was observed.Results There were 80 cases of natural labor,25 cases of cesarean section in 105 cases of pregnant women with drug abuse.Among them,56 cases (53.3 ％) of premature delivery,the average birth weight was(2 534 ± 1 234) g,25 cases(23.8％) of neonatal asphyxia,18 cases(17.1％) of neonatal respiratory distress syndrome (NRDS),16 cases (15.2 ％) of intracranial hemorrhage,and 3 cases (2.9 ％) of congenital malformation.The gestational age and weight of newborn with maternal drug abusing were significantly lower than those of the control group,the incidence of premature infants,low birth weight infants,neonatal asphyxia,NRDS and intracranial hemorrhage were higher than those of the control group,and the differences were significant (P ＜ 0.05).Compared with drug abuse less than 2 years,the proportion of preterm infants,low birth weight,neonatal asphyxia and NRDS were higher than those of drug abuse more than 2 years(P ＜0.05).The proportion of preterm infants,low birth weight,neonatal asphyxia and NRDS of intravenous drug users were higher than those of oral drug users,the differences were significant (P ＜ 0.05).The red blood cellcount,aspartate amino transferase,white blood cellcount and alanine aminotransferase in the drug abusing group were higher than those in the control group,platelet and albumin were lower than those in the control group (P ＜0.05).A total of 30 neonates had the manifestations of neonatal withdrawal syndrome.In 105 cases of newborns,99 cases cured,6 cases died,the cure rate was 94.3％.The causes of death included 3 cases of NRDS complicated with pulmonary infection,1 case of severe intracranial hemorrhage,1 case of asphyxia,and 1 case of multiple organ failure.Conclusion Drug abuse can lead to the increase of premature birth rate,asphyxiation and NRDS.Late pregnant women with drug abuse can cause the incidence of neonatal withdrawal syndrome.