A Case of Transformation of Mycosis Fungoides to Large Cell Lymphoma / 대한피부과학회지

ABSTRACT

Cutaneous T cell lymphoma (mycosis fungoides/Sezary syndrome) is a clonal malignacy of helper (CD4+) T lymphocytes usually first detected in the skin. In 8-55% of mycosis fungoides, the malignant T cell clone undergoes, cytologic transformation characterized by pleomorphic, large cells with prominent nucleoli, resulting in the morphologic appearance of a large cell lymphoma. The prognosis of large cell transformation of mycosis fungoides is poor; so detection of cytologic transformation is important to decide further treatment. We report a case of 22-year-old mycosis fungoides patient who developed large cell transformation during photochemotherapy (PUVA).