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Association of Apolipoprotein A5 (c.553G/T) gene polymorphism with hypertriglyceridemia of the Han Nationality in Zunyi / 实用医学杂志
The Journal of Practical Medicine ; (24): 3386-3390, 2016.
Artigo em Chinês | WPRIM | ID: wpr-503278
ABSTRACT
Objective To investigate the relativity between c.553G/T polymorphism in exon 4 of Apolipoprotein A5 gene and hypertriglyceridemia (HTG) in Zunyi Han Nationality. Methods c.553G/T polymorphism of 103 HTG patients and 165 healthy individuals were tested by polymerase chain reaction and restriction fragment length (PCR-RFLP) assay. The distributions of genotypes and allele frequencies in HTG patients and healthy group were analyzed between Zunyi population and others. Results The genotype frequency of the Apo A5 gene c.553G/T showed statistical difference between patients group and normal groups (P 0.05). In HTG groups, gene frequency of Zunyi was similar to that in Jiangsu (P>0.05), but higher than that in Xinjiang (P 0.05). Conclusion There is relativity between Apo A5 gene c.553G/T polymorphisms and HTG in Zunyi Han nationality and the differences vary across different areas. It could be an independent risk factor for HTG.

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Tipo de estudo: Fatores de risco Idioma: Chinês Revista: The Journal of Practical Medicine Ano de publicação: 2016 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Tipo de estudo: Fatores de risco Idioma: Chinês Revista: The Journal of Practical Medicine Ano de publicação: 2016 Tipo de documento: Artigo