Formula Optimization of Shengmai Dispersible Tablets by Uniform Design / 中国药师
China Pharmacist
;
(12): 1980-1983, 2016.
Artigo
em Chinês
| WPRIM
| ID: wpr-503308
ABSTRACT
Objective:
To explore the formula and preparation technology parameters of Shengmai dispersible tablets.Methods:
With the granulation status, disintegration time, friability, taste and and so on as the testing indices, the formula and preparation tech-nology of Shengmai dispersion tablets were optimized by uniform design.Results:
The optimized formula of Shengmai dispersible tab-lets was as follows25% extract powder, 58% MCC, 8% CCMC-Na, 4% CMS-Na, 2% L-HPC, 2% magnesium stearate and 1%sweetener. L-HPC and magnesium stearate were added after the granulation, and the tablet hardness was controlled at 25N. The opti-mized dispersible tablets could disintegrate uniformly within 3 min.Conclusion:
The optimization of the prescription and preparation process parameters of Shengmai dispersing tablets is stable and reliable, and has good repeatability, and the process is feasible.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
China Pharmacist
Ano de publicação:
2016
Tipo de documento:
Artigo
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