Determination of Carfilzomib for Injection by HPLC / 中国药师
China Pharmacist
;
(12): 1959-1960, 2016.
Artigo
em Chinês
| WPRIM
| ID: wpr-503315
ABSTRACT
Objective:
To establish an HPLC method to determine the content of carfilzomib for injection.Methods:
The chroma-tographic column was a Waters symmetry C18(250 mm ×4.6 mm, 5 μm)column, the sample solvent was methanol, the mobile phase was 0. 05% trifluoroacetic acid-acetonitrile(57 ∶43) at a flow rate of 1. 0 ml · min-1 , the detection wavelength was 210 nm, the col-umn temperature was 25℃ and the injection volume was 10 ml.Results:
The linear range of carfilzomib was 120-600 μg·ml-1 ( r=0. 999 7). The average recovery was 100. 4%( RSD=0. 24%,n=9).Conclusion:
The method is rapid and effective, which can be used for the content determination of carfilzomib for injection.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
China Pharmacist
Ano de publicação:
2016
Tipo de documento:
Artigo
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