Analysis of 58 Cases of ADR/ADE with Cardiac Damage Induced by Metranidazole / 中国药房
China Pharmacy
;
(12): 3643-3645, 2016.
Artigo
em Chinês
| WPRIM
| ID: wpr-503453
ABSTRACT
OBJECTIVE:
To explore the characteristics and regularities of cardiac damage induced by metranidazole,and pro-vide reference for clinical safe application.METHODS:
In retrospective study,58 cases of cardiac damage caused by metranidazole in Henan ADR Monitoring Center for Drug from Jan. 2010 to Dec. 2015 were analyzed statistically.RESULTS:
In 58 cases of cardiac damage induced by metranidazole,25 cases were male,33 were female,the ratio of male to female was 0.76∶1,the patients with ADR/ADE aged 15-64 years (74.14%),most were intravenous administration (79.31%) and happened within 30 min (70.69%), cardiac damage mainly manifested as palpitation,severe cases can cause tachycardia and arrhythmia,the ADR improved or cured af-ter withdrawal or symptomatic treatment.CONCLUSIONS:
Clinic should strengthen observation of ADR/ADE caused by metranida-zole,especially the monitoring of cardiac toxicity reactions;pharmaceutical manufacturers should improve the drug instructions to in-sure the safety of clinical medication.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo observacional
Idioma:
Chinês
Revista:
China Pharmacy
Ano de publicação:
2016
Tipo de documento:
Artigo
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