Research progress of medical therapies for chronic myeloid leukemia / 中国生化药物杂志

ABSTRACT

Chronic myeloid leukemia(CML)is a pluripotent stem cell disease characterized by the proliferation of myeloid cell.Ph chromosome has been found in 95% of CML patients.BCR-ABL fusion protein expressing on Ph chromosome displayed constitutive tyrosine kinase activity.The fusion protein could phosphorylate and activate downstream substrates continually in the process of cell signal transduction,and then cells proliferate and migrate constantly,resulting the occurrence of CML.In recent years, people have been tried various methods to cure CML, which included developing some chemotherapy drugs and herbal extracts,as well as designing and synthesizing the inhibitors targeting BCR-ABL tyrosine kinase.Clinical studies showed that these drugs have been achieved remarkable effects.This paple aimed to review for drugs treated in CML.