Evaluation of Measurement Uncertainty for the Content of Bisacodyl Enteric-coated Tablet by HPLC / 中国药房
China Pharmacy
;
(12): 3428-3430, 2016.
Artigo
em Chinês
| WPRIM
| ID: wpr-504928
ABSTRACT
OBJECTIVE:
To a evaluation method for the measurement uncertainty for the content of Bisacodyl enteric-coated tablet.METHODS:
HPLC external standard method was conducted for content determination of Bisacodyl enteric-coated tablet, and mathematical model for uncertainty evaluation was established to systematically analyze and evaluate the influential factors in processes of solution preparation and instrument measurement.RESULTS:
HPLC external standard method showed the content was 97.8%,confidence probability was 95%,expanded uncertainty was 2.8%,and determination result was (97.8 ± 2.8)%,k=2.CONCLUSIONS:
The established method is suitable for the evaluation of measurement uncertainty for the content of Bisacodyl en-teric-coated tablet. Regularly calibrated verification for HPLC equipment and strict control of the weighing process will help to im-prove the accuracy measured by HPLC.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo prognóstico
Idioma:
Chinês
Revista:
China Pharmacy
Ano de publicação:
2016
Tipo de documento:
Artigo
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