Pathogenesis of endothelial cell dysfunction in chronic kidney disease: a retrospective and what the future may hold
Kidney Research and Clinical Practice
; : 76-82, 2015.
Article
em En
| WPRIM
| ID: wpr-50612
Biblioteca responsável:
WPRO
ABSTRACT
Cardiovascular complications dominate the landscape of chronic kidney diseases (CKD). Endothelial cell dysfunction (ECD) is a well-known culprit of cardiovascular morbidity and it develops in CKD with remarkable frequency. This brief overview of ECD in CKD scans two decades of studies performed in my laboratory, from genetic analyses to proteomic and metabolomics screens. I provide a detailed description of findings related to the premature senescence of endothelial cells, cell transition from the endothelial to mesenchymal phenotype, and stages of development of ECD. Clinical utility of some of these findings is illustrated with data on laser-Doppler flowmetry and imaging in patients with CKD. Some currently available and emerging therapeutic options for the management of ECD are briefly presented.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Fenótipo
/
Envelhecimento
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Estudos Retrospectivos
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Fluxometria por Laser-Doppler
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Células Endoteliais
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Insuficiência Renal Crônica
/
Metabolômica
Tipo de estudo:
Etiology_studies
/
Observational_studies
Limite:
Humans
Idioma:
En
Revista:
Kidney Research and Clinical Practice
Ano de publicação:
2015
Tipo de documento:
Article