Can serum interleukin-2 receptor alpha predict lymph node metastasis in early gastric cancer? / 대한외과학회지
Journal of the Korean Surgical Society
;
: 143-148, 2012.
Artigo
em Inglês
| WPRIM
| ID: wpr-50640
ABSTRACT
PURPOSE:
Although local resection like endoscopic mucosal resection for early gastric cancer is accepted as a treatment option, one of the most important drawbacks of such an approach is the inability to predictlymph node metastasis. The aim of this study was to evaluate the serum soluble receptor alpha for interleukin-2 (IL-2Ralpha) level as a predictor of lymph node metastasis in the patients with early gastric cancer.METHODS:
Assessment of pre-operative serum IL-2Ralpha levels was performed on 86 patients with early gastric cancer treated by gastrectomies combined with D2 lymph node resections and 20 healthy controls at Samsung Medical Center. Data on patient age and gender, tumor size, depth of invasion, histologic differentiation, and endoscopic findings were reviewed post-operatively. The submucosal lesions were divided into three layers (sm1, sm2, and sm3) in accordance with the depth of invasion.RESULTS:
Lymph node metastasis was observed in 16 patients (18.6%). Statistically, the serum IL-2Ralpha level was an important predictive factor of lymph node metastasis in undifferentiated gastric cancer, and the cut-off point for the predictive value of serum IL-2Ralpha level was 200 U/mL.CONCLUSION:
The serum IL-2Ralpha level might be a good predictor of lymph node metastasis in undifferentiated early gastric cancer.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Neoplasias Gástricas
/
Biomarcadores
/
Interleucina-2
/
Subunidade alfa de Receptor de Interleucina-2
/
Gastrectomia
/
Linfonodos
/
Metástase Linfática
/
Metástase Neoplásica
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Journal of the Korean Surgical Society
Ano de publicação:
2012
Tipo de documento:
Artigo
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