Research progress on components in human milk and their mechanism for preventing necrotizing enterocolitis / 中华实用儿科临床杂志

ABSTRACT

Necrotizing enterocolitis (NEC) is one of the common intestinal critical disease in newborns especially in premature infants.However,the etiology and pathogenesis of NEC are not fully clear.There were a lot of research which had shown that breast-feeding could significantly reduce the incidence of NEC.The composition in human milk,such as human milk oligosaccharides,growth factors,glutamine,lactoferrin,has effects on anti-infection,maintaining intestinal mucosal integrity and immune regulation,and the proportion of nutrients,and osmotic pressure in human milk is especially suitable for the needs of gastrointestinal physiological of premature infants,which can effectively prevent the happening of the NEC.Now,the research progress on components in human milk and their mechanism for preventing necrotizing enterocolitis was reviewed.