Lactoferrin and necrotizing enterocolitis in preterm infants / 国际儿科学杂志

ABSTRACT

Necrotizing enterocolitis(NEC)in neonates is the most important neonatal problems in nursery and is associated with high neonatal mortality and morbidity.NEC also leads to various long term complications,including short bowel syndrome,systemic infection,eye problems,nutritional deficiency and neurodevelopmental impairments.Lactoferrin(LF) is a component of breast milk and has multiple actions include antimicrobial,antiviral,anti-fungal and enhance immunity and so on.Studies have been completed and a number of trails are going on for evaluation of efficacy and safety of LF in the prevention of NEC.LF prophylaxis and therapy may have a significant impact on improving clinical outcomes of vulnerable premature infants.