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Clinical Observation of Xingpi Yang'er Granule in the Treatment of Primary Nocturnal Enuresis in Chil-dren / 中国药房
China Pharmacy ; (12): 738-741, 2017.
Artigo em Chinês | WPRIM | ID: wpr-507597
ABSTRACT

OBJECTIVE:

To observe the efficacy and safety of Xingpi yang'er granule in the treatment of primary nocturnal en-uresis in children.

METHODS:

97 children with primary nocturnal enuresis were randomly divided into control group (46 cases) and observation group(51 cases). Control group received Racemic anisodamine tablet 0.5 mg/(kg.d),orally,once a day+Vitamin B1 tablet 10 mg,orally,3 times a day+Oryzanol tablet 10 mg,orally,3 times a day + Meclofenac hydrochloride capsule 0.1 g 30 min before going to bed,orally,once a day. Observation group was additionally received Xingpi yang'er granule 0.4 g for 5-6 years old and 0.6 g for 7-14 years old,3 times a day. They were treated for 4 weeks. Clinical efficacy,kidney Yang deficiency score,wake-up threshold,bladder capacity,bladder volume,BVWI,enuresis frequency,AVP,cAMP,cGMP,cAMP/cGMP be-fore and after treatment,recurrence rate and the incidence of adverse reactions in 2 groups were observed.

RESULTS:

The total ef-fective rate in observation group was significantly higher than control group(P0.05);after 6 months,the total effective rate recur-rence rate in observation group was significantly lower than control group(P0.05).

CONCLUSIONS:

Based on conventional treatment,Xingpi yang'er granule shows good efficacy and safety in the treatment of primary nocturnal enuresis in children,which can improve children's kidney Yang deficiency score,wake-up threshold and bladder capacity and serum AVP.

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: China Pharmacy Ano de publicação: 2017 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: China Pharmacy Ano de publicação: 2017 Tipo de documento: Artigo