Correlation Study Between Serum Level of LncRNA KCNQ1OT1 Overlapping Transcript and Coronary Artery Lesion in Relevant Patients / 中国循环杂志
Chinese Circulation Journal
;
(12): 36-40, 2017.
Artigo
em Chinês
| WPRIM
| ID: wpr-508044
ABSTRACT
Objective:
To investigate the serum expression of long non-coding RNA overlapping transcription content KCNQ1OT1 (KCNQ1) gene in patients with coronary artery disease (CAD) and its clinical significance.Methods:
A total of 196 patients treated in our hospital were divided into 2 groupsCAD group and Control group, the patients were without CAD. n=98 in each group. Expression levels of serum KCNQ1OT1 and P53 were measured by quantitative RT-PCR;the relationship between KCNQ1OT1, P53 and clinical features in relevant patients were analyzed.Results:
Compared with Control group, CAD group had increased expression of serum KCNQ1OT1 and decreased expression of P53, both PConclusion:
CAD patients had obviously increased serum level of KCNQ1OT1;KCNQ1OT1 was independently related to CAD occurrence.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Circulation Journal
Ano de publicação:
2017
Tipo de documento:
Artigo
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