Research Progress in Anti-tumor Drugs Based on Microtubules Targets / 中国药师

ABSTRACT

Microtubules are the important components in cytoskeleton, which are found in all eukaryotic cells. Microtubules can assemble with the other proteins to form spindle, centriole and neural tube structure. Microtubules play important roles in cell mitosis, intracellular transportation, cell shape maintenance and signal transduction process. Microtubules are the important targets in many drug discoveries. The antitumor drugs acting on microtubules are the most effective clinical drugs, which can inhibit the polymerization of microtubules, destroy microtubules dynamic balance and spindle, block cell cycle and induce tumor cells necrosis. The paper re-viewed the effects and action mechanisms of microtubules targeted antitumor drugs, and discussed their application prospects in clinics.