The effects of spironolactone on cardiovascular function in patients undergoing maintenance hemodialysis / 重庆医学

ABSTRACT

Objective To explore the effects of spironolactone on cardiovascular function in patients undergoing maintenance hemodialysis .Methods According to the random number table ,80 cases of patients undergoing maintenance hemodialysis in blood purification center of our hospital from December 2013 to June 2015 were randomly divided into the observation group and control group ,40 cases in each group .In the observation group ,patients were treated with spironolactone therapy ,while patients in the con‐trol group took a placebo .The cardiovascular function and related indexes were compared between the two groups .Results After 6 months of treatment ,the HR and BNP were decreased ,and CO ,SV ,SI and CI were increased in the observation group ,statistically significant differences were found in these indexes when compared with the control group (P0 .05) .The PP ,MSP ,MDP ,MAP and ET‐1 in the observation group were significantly decreased after 6 months of treatment ,which were statistically different with those in the control group (P<0 .05) . Conclusion Spironolactone contributes to improving cardiovascular function of patients undergoing maintenance hemodialysis ,it is worthy of clinical application .