Bone marrow mesenchymal stem cell transplantation alleviates myocardial injury due to systolic hypertension / 中国组织工程研究
Chinese Journal of Tissue Engineering Research
;
(53): 7518-7523, 2016.
Artigo
em Chinês
| WPRIM
| ID: wpr-508664
ABSTRACT
BACKGROUND:
Mesenchymal stem cel s can be used to treat a variety of injuries, but little is known about their effect on systolic hypertension.OBJECTIVE:
To study the therapeutic effect of bone marrow mesenchymal stem cel s on systolic hypertension rats.METHODS:
Twenty-four rats were randomized equal y into control, model and cel transplantation groups. A rat model of systolic hypertension was made by injection of vitamin K and warfarin sodium in the model and cel transplantation groups. Rats in the cel transplantation group were given injection of bone marrow mesenchymal stem cel s into the left ventricle, while those in the other two groups given normal saline. RESULTS ANDCONCLUSION:
Compared with the model group, bone marrow mesenchymal stem cel s could reduce left ventricular mass index, increase cardiac tissue type I col agen volume fraction, col agen volume fraction and perivascular col agen volume fraction, but the ratio of end-diastolic volume/body weight did not change significantly. These findings indicate that bone marrow mesenchymal stem cel transplantation can reduce myocardial hypertrophy and cardiac fibrosis in systolic hypertension rats.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Ensaio Clínico Controlado
Idioma:
Chinês
Revista:
Chinese Journal of Tissue Engineering Research
Ano de publicação:
2016
Tipo de documento:
Artigo
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