Hyaluronate acid and oxidized regenerated cellulose prevent adhesion reformation after adhesiolysis in rat / 重庆医学

ABSTRACT

Objective To evaluate the effect of pelvic adhesiolysis to prevent readhesion in the second look operation.Methods 30 rats underwent laparotomy incision of uterus to create intraperitoneal adhesions models.The animals were randomly divided into three groupsthe first groupisotonic Na chloride (n =10);the second groupmedical Sodium Hyaluronate (n =10),the third groupOxidized regenerated cellulose.After 2-week recovery period,the animals were operated andintraperitoneal adhesions were assessed,then,all adhesions were released and set isotonic Na chloride,medical Sodium Hyaluronate and Oxidized regenerated cellulose.Again,After 2-week recovery period,the animals were killed and the intraperitoneal adhesions were assessed.Results After the first operation the three groups had significant difference (F=7.114,P＜0.05),After the second operation the three groups had no significant difference(F=0.280,P＞0.05).Conclusion Medical sodium hyaluronate and oxidized regenerated cellulose are effective methods to prevent postoperative adhesions.However,they are ineffective to prevent readhesion after adhesiolysis.