Clinical study of abdominl type of tumor cells to destroy the loss after neoadjuvant chemotherapy in treatment of epithelial ovarian cancer stage Ⅲ C / 中国综合临床

ABSTRACT

Objective To investigate the effect of abdominl type of tumor cells to destroy the loss after neoadjuvant chemotherapy in treatment of epithelial ovarian cancer stage Ⅲ C.Methods Eighty cases patients of stage ⅢC epithelial ovarian cancer who were treated in Traditional Chinese Medicine Hospital of Meizhou from June 2010 to June 2012 were enrolled in this study and all were consistent with the diagnostic criteria and no operation contraindications.They were randomly divided into two groups with 40 cases in each group according to the paired grouping method.The observation group was treated with abdominal type intermediate tumor cell reduction surgery after neoadjuvant chemotherapy,and the control group was treated with abdominal intermediate tumor cells.Two groups were treated by paclitaxel and carboplatin chemotherapy after the operation,the curative effect between the two groups was compared.Results Blood loss during operation of patients in observation group were lower than control group,the difference was significant((512.6±98.6) ml vs.(785.6±91.2) rnl,P＜0.001).The operation time of patients in observation group was shorter than that of control group,the difference was significant((215.6±42.6) min vs.(285.6±43.9) min,P＜0.01).The ascites of patients in observation group were less than that of control group,the difference was significant((689.5±215.6) ml vs.(1 265.9±325.6) ml,P＜0.01).There was no significant difference in the length of stay between the two groups (P＞0.05).There were 11 cases(27.5％) of complete remission,24 cases(60.0％) of partial remission,4 cases of stable (10％,4/40),1 case (2.5％,1/40) of progress in the observation group recently;while in control group,complete remission in 5 cases(12.5％),partial remission in 9 cases (22.5％),stable in 20 cases(50％,20/40),progress in 6 cases (15.0％,6/40),the differences between the two groups were statistical significance (P＜0.001).The 3 year survival rate of observation group was significantly higher than that of control group (92.5％ vs.72.5％,P =0.0394).Conclusion The effect of abdominl type of tumor cells to destroy the loss after neoadjuvant chemotherapy in treatment of epithelial ovarian cancer stage ⅢC is better,it has the important clinical value.