Expression of LDHA in breast cancer and its clinical significance / 中国医师杂志
Journal of Chinese Physician
;
(12): 207-209, 2017.
Artigo
em Chinês
| WPRIM
| ID: wpr-509987
ABSTRACT
Objective To investigate the expression and clinical significance of lactate dehydrogenase A (LDHA) in breast cancer.Methods Tissue samples of 76 breast cancers and corresponding paired adjacent normal tissues were collected and made into tissue micrcarrays (TMAs).Immunohistochemistry (IHC) analysis was performed to detect the expression of LDHA and further analyzed the correlation of LDHA expression and clinicopathological variables and prognosis of breast cancers.Results LDHA was frequently upregulated in breast cancer tissues compared to the normal breast tissues (P < 0.05).High LDHA expression was associated with distant metastasis (P < 0.05) and worse patient prognosis (P < 0.05).Conclusions LDHA is closely related to the occurrence and clinical progress of breast cancers.LDHA might be a potential novel molecular marker for diagnosis,prognosis and therapy in breast cancers.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of Chinese Physician
Ano de publicação:
2017
Tipo de documento:
Artigo
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