Remission rates in patients with refractory skin graft-versus-host disease treated with extracorporeal photopheresis: a meta-analysis / 中华皮肤科杂志
Chinese Journal of Dermatology
;
(12): 286-290, 2017.
Artigo
em Chinês
| WPRIM
| ID: wpr-511351
ABSTRACT
Objective To systematically analyze therapeutic effects of extracorporeal photopheresis (ECP) on refractory steroid-resistant,-dependent or-intolerant graft-versus-host disease (GVHD),to compare remission rates of skin GVHD in detail.Methods Databases were searched for studies concerning remission rates of GVHD after the treatment with ECP,and relevant data were extracted and pooled by using meta-analysis with STATA 12.0 software.Results A total of 22 literatures were reviewed,including 787 patients with refractory GVHD.Meta-analysis showed that the pooled complete remission (CR) rate and overall remission (OR) rate were 57% (95% CI47%-66%) and 79% (71%-86%) respectively in patients with acute GVHD,27% (21%-33%) and 63% (58%-69%) respectively in patients with chronic GVHD,77% (71%-82%) and 87% (82%-91%) in patients with acute skin GVHD,as well as 39% (30%-48%) and 70% (63%-77%) in patients with chronic skin GVHD.Conclusion ECP is an effective therapy for refractory GVHD,especially for skin GVHD.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Revisões Sistemáticas Avaliadas
Idioma:
Chinês
Revista:
Chinese Journal of Dermatology
Ano de publicação:
2017
Tipo de documento:
Artigo
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