Effects of interaction Cd-Zn on serum-PSA level and prostate histology in rats
Asian Pacific Journal of Tropical Biomedicine
;
(12): 245-248, 2017.
Artigo
em Chinês
| WPRIM
| ID: wpr-511486
ABSTRACT
Objective:
To assess cadmium sulfate (CdSO4) and zinc chloride (ZnCl2) antagonist effects on the prostate specific antigen and prostatic cell organization in rats.Methods:
The study included 40 adult male rats, divided into four groups Group 1 (CdSO4), Group 2 (ZnCl2), Group 3 (CdSO4-ZnCl2) and Group 4 (control). Animals were treated with CdSO4 and ZnCl2 at the same dose (15 mg/L) during 30 days.Results:
It was showed a higher body weight and a lowering serum-prostate specific antigen concentration [(1.8 ± 0.6) ng/mL] in animals treated with CdSO4. CdSO4 induced a cyto-nuclear atypia, proliferative lesions, hyperplasia and precancerous foci in prostate tissue. Toxic effects of ZnCl2 were not recorded in this study.Conclusions:
Protective role of zinc was exhibited against toxic effects of cadmium in prostate gland.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Asian Pacific Journal of Tropical Biomedicine
Ano de publicação:
2017
Tipo de documento:
Artigo
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