Cytotoxicity of Ibuprofen Raw Material and its Part of Impurities / 中国药师
China Pharmacist
; (12): 769-771, 2017.
Article
em Zh
| WPRIM
| ID: wpr-511637
Biblioteca responsável:
WPRO
ABSTRACT
Objective:To evaluate the cytotoxicity of ibuprofen and its 6 kinds of impurities.Methods:Different concentrations of ibuprofen and the impurities were used to act on mouse fibroblasts (L929) for 72 h,and the cytotoxicity was observed under a microscope.Results:In ibuprofen raw material,the cytotoxicity of impurity B was the weakest with slight toxicity,the cytotoxicity of impurity N,D,J and V was moderate,and that of impurity E was severe.Conclusion:At the same concentration,the toxicity of impurity E is the strongest,and its content in ibuprofen preparations should be strictly controlled.
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Índice:
WPRIM
Idioma:
Zh
Revista:
China Pharmacist
Ano de publicação:
2017
Tipo de documento:
Article