Neutrophilic Leukemoid Reaction Associated with Malignancy Initially Suspected as Chronic Neutrophilic Leukemia
Laboratory Medicine Online
;
: 206-210, 2017.
Artigo
em Inglês
| WPRIM
| ID: wpr-51167
ABSTRACT
Although neutrophilia can manifest from various causes, it is important to be able to distinguish chronic neutrophilic leukemia (CNL) from neutrophilic leukemoid reactions (NLR). In this paper, we describe four cases of leukocytosis with neutrophilia, including one case of CNL with a T618I mutation in colony stimulating factor 3 receptor (CSF3R) and three cases of NLR associated with malignancy or sepsis, which were initially suspected as CNL. Of the three NLR cases, one was associated with ovarian cancer, one with monoclonal gammopathy of undetermined significance and one with multiple myeloma with sepsis. This study demonstrated that confirming the clonality of myeloid cells with CSF3R T618I could contribute to making an accurate differential diagnosis between CNL and NLR in patients with solid cancers or plasma cell neoplasms caused by paraneoplastic syndromes and/or infection.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Neoplasias Ovarianas
/
Síndromes Paraneoplásicas
/
Gamopatia Monoclonal de Significância Indeterminada
/
Leucemia Neutrofílica Crônica
/
Fatores Estimuladores de Colônias
/
Sepse
/
Células Mieloides
/
Diagnóstico Diferencial
/
Neoplasias de Plasmócitos
/
Reação Leucemoide
Tipo de estudo:
Estudo diagnóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Laboratory Medicine Online
Ano de publicação:
2017
Tipo de documento:
Artigo
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