Effect of fluconazole capsules combine with Zhibai dihuangwan on serum IL-10, TNF-α and clinical effect on trichomonas vaginitis patients / 中国生化药物杂志

ABSTRACT

Objective To investigate the fluconazole capsule combined with Zhibaidihuangwan on Trichomonas vaginitis patients on serum IL-10,TNF-α and clinical effect.Methods 78 cases of trichomonas vaginitis patients were collected in our hospital,randomly divided into two groups experimental group and control group,with 39 cases in each.After admission,the patients in the control group received fluconazole 0.2g,onetimes aday; patients in the experimental group on the basis of the control group given Zhibai dihuangwan eight pills/time,threetimes a day,continuous treatment for fourweeks.Observation and comparison of two groups of patients before and after treatment of interleukin-10(IL-10),tumor necrosis factor alpha(TNF-α),the patient's vaginal health score and the level of clinical efficacy.Results compared with before treatment,IL-10,TNF-α levels were decreased after treatment of the two groups,the difference is statistically significant(P<0.05); Compared with the control group,IL-10,TNF-α is low of patients in the experimental group,the difference has statistical significance(P< 0.05);Compared with before treatment,the patients in the two groups of vagina health score were significantly increased after treatment,the difference is statistically significant(P<0.05); Compared with the control group,the vagina health score is higher in experimental group patients,the difference is statistically significant(P< 0.05); Compared with the control group,the the total efficiency is higher of patients in the experimental group,the difference is statistically significant(P<0.05).Conclusion fluconazole capsule combined with Zhibaidihuangwan can reduce trichomonad vaginitis patients serum IL-10,TNF-α levels,improve clinical symptoms,clinical curative effect is better.