High Dose Intravitreal Bevacizumab for Refractory Pigment Epithelial Detachment in Age-related Macular Degeneration
Korean Journal of Ophthalmology
;
: 265-271, 2016.
Artigo
em Inglês
| WPRIM
| ID: wpr-51224
ABSTRACT
PURPOSE:
Intravitreal anti-vascular endothelial growth factor (anti-VEGF) is the first choice of treatment for age-related macular degeneration. However, quite a few eyes treated using conventional dose anti-VEGF (CDAV) have persistent pigment epithelial detachment (PED) on optical coherence tomography. This study investigated the efficacy and safety of high dose anti-VEGF (HDAV) for refractory PED.METHODS:
In this retrospective study, 31 eyes of neovascular age-related macular degeneration patients with persistent PED findings despite six or more intravitreal injections of CDAV (bevacizumab 1.25 mg or ranibizumab 2.5 mg) were analyzed. Changes in visual outcome, central foveal thickness, and PED height were compared before and after HDAV (bevacizumab 5.0 mg) for these refractory PED cases.RESULTS:
The mean age of patients was 67.7 years. The number of CDAV injections was 12.1. The number of HDAV injections was 3.39. Best-corrected visual acuity in logarithm of the minimum angle of resolution before and after HDAV was 0.49 and 0.41 (p < 0.001), respectively. Central foveal thickness before and after HDAV was 330.06 and 311.10 µm (p = 0.125), respectively. PED height before and after HDAV was 230.28 and 204.07 µm (p = 0.014), respectively. There were no serious adverse reactions in all the eyes.CONCLUSIONS:
Increasing the dose of bevacizumab in refractory PED may be a possible treatment option.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Descolamento Retiniano
/
Angiofluoresceinografia
/
Estudos Retrospectivos
/
Inibidores da Angiogênese
/
Fator A de Crescimento do Endotélio Vascular
/
Tomografia de Coerência Óptica
/
Relação Dose-Resposta a Droga
/
Epitélio Pigmentado da Retina
/
Injeções Intravítreas
/
Bevacizumab
Tipo de estudo:
Estudo observacional
Limite:
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Korean Journal of Ophthalmology
Ano de publicação:
2016
Tipo de documento:
Artigo
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