Expression and clinnical significance of NF-κB and CD147 in lung adenocarcinoma / 实用医学杂志

ABSTRACT

Objective To investigate the expression of NF-κB and CD147 in lung adenocarcinoma.Methods The expressions of NF-κB and CD147 protein were detected on 80 lung adenocarcinoma tissue by S-P immunohistochemical method.The positive units(PUs) of NF-κB and CD147 were assessed quantitatively using Imagepro Plus image analysis softwore.Results NF-κB and CD147 protein positive intensity in lung adenocarcinoma was significantly higher than that in the non lung carcinoma (P =0.000,respectively).The positive rates of NF-κB and CD147 were 68.75％ (55/80) and 81.25％ (65/80) respectively.The expressions of NF-κB and CD147 were positively correlated with the degree of histologic differentiation,lymph node metastasis status and TNM stage (P =0.000,respectively).Both of them were not associated with sex,age,patients with history smoking,and tumor located in the central (P ＞ 0.05,respectively).NF-κB was correlated positively with CD147 expression (rp =0.498,P =0.000).Conclusions The high expression of NF-κB in lung adenocarcinoma may promote the high expression of CD147,and promote the tumor invasion and metastasis.