The clinical value of mean platelet volume and neutrophil to lymphocyte ratio for the short-term prognosis in elderly patients with acute exacerbations of chronic obstructive pulmonary disease / 实用医学杂志

ABSTRACT

Objective To explore the association of mean platelet volume and neutrophil to lymphocyte ratio with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)in elderly patients and its clinical value for the short-term prognosis. Methods A total of 52 patients with AECOPD who had been hospitalized during the period of April 2014 to April 2015 were enrolled in this prospective observational study. Levels of mean platelet volume (MVP),C-reactive protein,complete blood count,D-dimer,fibrinogen,percent-of-predicted FEV1 and percent-of-predicted FEV1/FVC were measured at admission(acute exacerbation)and after 3 months(stable period). Fifty-two age-and sex-matched healthy individuals constituted the control group. Pearson′s correlation was used to analyze the association of MPV with WBC,NLR,CRP,DD,FIB,FEV1%,and FEV1/FVC%. Results In AECOPD,as compared with stable COPD and the control group,levels of WBC,NLR,D-dimer,fibrinogen and CRP elevated;FEV1,FVC,percent-of-predicted FEV1 and percent-of-predicted FEV1/FVC declined;and MPV level decreased obviously. As a cut-off point of MVP level of<8.35fl for predicting AECOPD,it showed a sensitivity of 84.6%and a specificity of 86.5%. A decreased MVP level was significantly correlated with an increased in white blood cell count, neutrophil to lymphocyte ratio,D-dimer,fibrinogen and C-reactive protein level(P=0.01,0.02,0.01,0.02,and 0.01 respectively). Conclusions Mean platelet volume and neutrophil to lymphocyte ratio may be inflammatory markers inAE COPD,and measurement of mean platelet volume level may be useful for identifying elderly patients at increased risks for acute exacerbation.