Role of cannabinoid receptor Ⅰ-mediated synaptic plasticity in neuropathic pain and associated depression / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 340-345, 2017.
Artigo
em Chinês
| WPRIM
| ID: wpr-513238
ABSTRACT
Neuropathic pain is a class of pain caused by an injury or diseases of the somatosensory system and characterized by spontaneous pain,allodynia,and hyperalgesia.It is well established that central sensitization is one of the key mechanisms underlying the development and maintenance of neuropathic pain.Cannabinoid receptor 1 (CB1R) of endocannabinoid system modulates synaptic transmission,regulates synaptic plasticity,inhibits central sensitization,and thus attenuates neuropathic pain.Recent studies have shown that activation of CB1R also involves in the relief of neuropathic pain-induced depression.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of Central South University(Medical Sciences)
Ano de publicação:
2017
Tipo de documento:
Artigo
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