Correlation between zinc-α2-glycoprotein and hyperuricemia / 医学研究生学报

ABSTRACT

Objective Few reports are seen about the relationship of zinc-α2-glycoprotein ( ZAG ) with hyperuricemia ( HUA) . This study aimed to explore the correlation between ZAG and HUA by detecting the mRNA and protein expressions of ZAG in patients with HUA and in healthy subjects with normal uric acid ( NUA) . Methods We enrolled 74 HUA patients and another 74 NUA subjects in this study. We collected blood samples for determination of the mRNA and protein expressions of serum ZAG by real-time PCR and ELISA respectively, followed analysis of the differences in the expressions of ZAG mRNA and protein between the two groups. Results Compared with the NUA subjects, the HUA patients showed significantly increased expressions of ZAG mRNA (11.731±4.033 vs 13.201±3.433, P<0.05) and ZAG protein (5.540±0.573 vs 6.163±1.779, P<0.05). The level of serum uric acid was correlated positively with the expressions of ZAG ( r=0.176) , BMI ( r=0.161) , SBP ( r=0.144) , DBP ( r=0.250) , BUN ( r=0.461) , CREA ( r=0.649) , and TG ( r=0.212) , but negatively with HDL ( r=-0.333) , all with statistically significant differences ( P<0.05) . Conclusion The expressions of ZAG mRNA and protein can be used as a new target for prevention and treatment of HUA and its related metabolic diseases.