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Mechanism of Neural Stem and Progenitor Cells Mediated by Hypoxia Inducible Factor-1α in Ischemic Stroke Model (review) / 中国康复理论与实践
Article em Zh | WPRIM | ID: wpr-514878
Biblioteca responsável: WPRO
ABSTRACT
Hypoxia inducible factor-1αis a kind of hypoxia response factor. Acute cerebral ischemia and anoxia can induce up-regula-tion of hypoxia inducible factor-1α, and the downstream genes, which plays a role in both the energy metabolism and collateral circulation after cerebral ischemia. Neural stem and progenitor cells regeneration also benefit the functional outcome after ischemic stroke. Hypoxia in-ducible factor-1αmay induce proliferation and differentiation of neural stem and progenitor cells through Notch, Wnt/β-catenin pathways, etc., in the ischemic stroke model.
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Texto completo: 1 Índice: WPRIM Idioma: Zh Revista: Chinese Journal of Rehabilitation Theory and Practice Ano de publicação: 2017 Tipo de documento: Article
Texto completo: 1 Índice: WPRIM Idioma: Zh Revista: Chinese Journal of Rehabilitation Theory and Practice Ano de publicação: 2017 Tipo de documento: Article