Research advances on effects of ursolic acid and oleanolic acid against hepatic steatosis and fibrosis / 药物评价研究

ABSTRACT

Anti-oxidation of ursolic acid and oleanolic acid antagonizes oxidative stress-induced lipid peroxidation,inflammatory injury,steatosis,and fibrosis in liver tissue.Ursolic acid and oleanolic acid could block static state hepatic stellate cells activation and proliferation,and promote active state hepatic stellate cells apoptosis,thus decrease expression of collagen,and increase decomposition of extracellular matrix,to produce the effect in prevention and treatment of hepatic fibrosis by obstruction of JAK2-STAT3 signal transduction to inhibit NOX activation.Ursolic acid and oleanolic acid induce expression of detoxification enzymes and effiux transporters to reduce serum levels of bile acids and bilirubin,and liver levels of bile acids in cholestatic animal,thus ameliorating cholestatic liver injury and fibrosis.Ursolic acid and oleanolic acid inhibit occurrence and development of hepatic steatosis via decreasing hyperlipidemia to inhibit lipid out of liver accumulating to liver,inhibiting hepatic lipid synthesis,and improving lipid metabolism.