Matrix Formulation Screening of Indomethacin Hydrophilic Gel Patch by Uniform Design / 中国药房
China Pharmacy
;
(12): 1382-1385, 2017.
Artigo
em Chinês
| WPRIM
| ID: wpr-515338
ABSTRACT
OBJECTIVE:
To screen the matrix formulation of Indomethacin hydrophilic gel patch.METHODS:
Using appear-ance,adhesion,softness,moisture retention as indexes,mixed level of uniform design was used to screen matrix formulation of patch,verification test and in vitro transdermal test were used to evaluate the patch quality.RESULTS:
Optimized matrix formula-tion was as follow as PVA of 7.686 g,PVP of 9.662 g,glyceryl of 19.992 g,gelatin of 9.999 g,CMC-Na of 13.997 g,carbomer of 3.000 g,HPMC of 1.500 g. The prepared patch had smooth surface,uniform matrix,good color,strong adhesion,good soft-ness(water loss rate of 11.9%). It can be slowly released for 48 h. The in vitro transdermal release fitted the Higuchi model(R2=0.9869).CONCLUSIONS:
Indomethacin hydrophilic gel patch is successfully prepared,which can slowly release drug with over-all good quality.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo diagnóstico
/
Estudo de rastreamento
Idioma:
Chinês
Revista:
China Pharmacy
Ano de publicação:
2017
Tipo de documento:
Artigo
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