Electromicroscopic observation on the prevention and treatment of experimental pulmonary edema in rat treated with anisodamine / 中国病理生理杂志

ABSTRACT

A preliminary study was conducted on prevention and treatment of adrenaline induced pulmonary edema in rat with anisodamine. An animal model of rat fatal pulmonary edema close to clinical neurogenic edema was made by intravenous injection of adrenaline. It is a kind of mixed pulmonary edema with both an increase in pulmonary capillary pressure and in permeability of pulmoary microvasculature. Anisodamine showed a pretty good preventive and therapeutic effect.The observation under eletron microscope(1) In the group of edema It showed that protein-rich fluid accumulated in the alveolar and interstitial space. The endothelial cells and epithelial cells were swollen and degenerated. Some of the basement membrance was lost and disintegrated.(2) In the group with anisodamine prevention and treatment It revealed that all of the pathological changes diminished. The epithelium and endothelium were normal, edema disappeared. The interstitial space widen and alveolar septal thicken which was due to the repair of the inflammation resulting in proliferation of connective tissue. The results showed that anisodamine cart inhibit the pulmonary microvascular and alveolar permeability as well.