An a-Adrenoceptor Blocking Action of Dihydrolycorine / 昆明医科大学学报
Journal of Kunming Medical University
; (12)1990.
Article
em Zh
| WPRIM
| ID: wpr-515874
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WPRO
ABSTRACT
Dihydrolycorine(DL)HCI was produced semisynthetically from lycorine which is an alkaloid isolated from lycoris radiata Herb.The dose-response curves for phenylephrine iv to increase mean arterial pressure were shifted rightward by DL 40 mg/kg iv in anesthetized cats.The dose- response curves for phenylephrine iv to increase diastolic pressure were shift- ed rightward by DL iv in pithed rats:but DL didn't shift the dose-response curves of BHT_(920).In rat anococcygeal muscle,DL 3,10,30,100uM/L shifted cumulative dose-response curves of methoxamine rightward parallelly with pa2 value 6.35.In the isolated rabbit aortic ring,DL 10,30,100uM/L also shifted cumulative dose-response curves of methoxamine rightward parallelly with pA2 value 5.93.These results suggest that DL can block a-adrenoceptors.
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Índice:
WPRIM
Idioma:
Zh
Revista:
Journal of Kunming Medical University
Ano de publicação:
1990
Tipo de documento:
Article