Clearance and detoxification of endotoxin by lung / 中国病理生理杂志

ABSTRACT

Endotoxin of in-and out-flowing pulmonary blood (IPB ,OPB) was measured by limulus chromogenic test in rabbits; Clearance of ~(51)Cr-E. coli endotoxin by lung was measured by a double indicator dilution method in rabbits; 12 and 24 hour's mortality rates was observed after E. coli endotoxin (1?g/100g b. w.) was infused through vein (ⅳ)and aorta (av)into the lead-sensitized rats. The endotoxin level of IPB (44.45?31.73 pg/ml plasma, n=13) was significantly higher than that of OPB (19.23?17.85 pg/ml plasma, n=13)in normal rabbits, (P