An experimental study of myocardial membrane injury in isoproterenol-induced myocardial infarction and the modulative effects of Svate / 中国病理生理杂志

ABSTRACT

Changes in lipids, enzymes and free-radical system of myocardial membranes were investigated in isoproterenol-induced myocardial infarction so as to study the modulative effects of Svate on myocardial membrane injury. Animals were killed 24h after ISP(85mg/kg) injection. The results suggested that disturbances in lipids metabolism, enzymes and free-radical system in ischemic myocardium, indicating the existence of myocardial membrane injury. In the Svate(0.25U/kg)-treated group, a beneficial effect of Svate exerted on membrane injury, as indicated by increased activities of GSH-Px, SOD and Na~+K~+-ATPase, and decreased Ch/PL ratio, MDA contents and Ca~(2+)-Mg~(2+)-ATPase activities.