Changes of essential trace elements contents in mouse brain tissue following acute and repeated exposure to hypoxia / 中国病理生理杂志

ABSTRACT

The present experiment was carried out on mice.The changes in contentsof 12 essential trace elements in the brain of mice were measured by inductivelycoupled plasma emission following acute and repetitive exposure to hypoxia.Followingrepeat exposure to hypoxia for one or two runs, the contents of non-soluble in brainhomogenats as was notably decreased,while that of the soluble V was markedly increased,when compared with that of normal group.When the animals were fed for two daysafter four runs of hypoxia,the contents of As,Fe,Cu,Co,Cr,B,and V were all signi-ficantly or very significantly changed in comparison with the normal value.Further stu-dies are needed to find out the biological importance of these changes and the relationshipbetween them and hypoxia tolerance.