Propofol hypnotic interaction with ketamine / 中华麻醉学杂志

ABSTRACT

The aim of this study was to investigate the hypnosis of the combination of propofol and ketamine. Two hundred healthy Kunming mites were randomly divided into five groups, and each groups included five subgroups receiving five designed doses in turn. Propofol or ketamine was administered in traperitoneally or subcutanously. The combination of propofol and ketamine was given in group Ⅱ, Ⅲ and Ⅳ, and propofol or ketamine in group Ⅰ or Ⅴ. The abolition of righting reflex lasting 10 seconds served as the parameter for hypnosis The data were treated with algebraic analysis. When the dose ratios of ketamine to propofol were 1 : 1.32, 1 : 5.28 and 1 : 0.33, the combined ED_(50) values were much more lower than those of the theoretical additive ED_(50). The sums of ratios of combined ED_(50) to single ED_(50) were less than 1.0. It is concluded that there is a hypnotic synergism between propofol and ketamine in mice