The role of tumor necrosis factor alpha in the pathogenesis of immunologically mediated aplastic anemia in mice / 中国病理生理杂志

ABSTRACT

The plasma levels of TNF alpha was determined dynamically using TNF ELISA; and TNF mRNA in spleen cells from varied groups was determined using Northern Blot. The results showed that: (1) Elevated levels of TNF-alpha in plasma from mice of immunologically- mediated aplastic anemia. (2) Induced production of TNF from spleen cells were much lower in exprimental groups than that in normal control group. (3) Decreased TNF-? gene expression present in spleen cell in AA group compared with normal control group.