Effects of aminoguanidine on endotoxin-treated rat aorta and pulmonary artery in vitro / 中华麻醉学杂志
Chinese Journal of Anesthesiology
;
(12)1996.
Artigo
em Chinês
| WPRIM
| ID: wpr-516746
ABSTRACT
Objective:
To investigate the effects of selective NOS inhibitor aminoguanidine (AG) on endotoxintreated rat aorta (AO) and pulmonary artery (PA) in vitro.Method:
The reaction to noradrenaline (NE) (10~(-9)-10~(-4)mmol/L) was measured in the vessels with complete endothelium, then the vessels were divided into 8 groups after incubated in LPS(300ng/ml)for 4 hours. Each group was incubated with AG(100?mol/L)or L-NAME (300?mol/L)for 20, or 60min, respectively.Result:
Both AO and PA showed hyporeaetivity to NE after incubated in LPS. and the reactivity of AO and PA to L-NAME and AG increased significantly after incubated in them for 60min or 20min. The sen sitivities of AO to AG,AO and PA to L-NAME increased greatly. AO had a higher reactivity to AG in 60min than in 20min. L-NAME caused earlier and greater contraction than AG in both 60 min and 20 min groups.Conclusion:
LNAME and AG can both increase the decreased reactivities of AO and PA to NE. AG only increases the AO sensitivity.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Anesthesiology
Ano de publicação:
1996
Tipo de documento:
Artigo
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